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KMID : 0363220200580060411
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Korean Journal of Dermatology
2020 Volume.58 No. 6 p.411 ~ p.415
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The Two Cases of Multifocal Fixed Drug Eruption Caused by Diclofenac
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Lee Ho-Jung
Hong Jung-Yeon
Park Tae-Heum
Lee Sung-Yul
Lee Jong-Suk
Chung Euy-Hyun
Lee Sang-Hoon
Kim Jung-Eun
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Abstract
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Fixed drug eruption (FDE) is a drug-induced disorder that may appear as patches or bullae. It recurs at the same sites as those involved in exposure to the same drug (causative drug). We encountered two cases of generalized FDE, and both patients had a history of diclofenac exposure before the onset of skin lesions. In the first case, an 82-year-old female patient presented with multiple erythematous patches on the trunk and lower extremities. In the second case, a 71-year-old male patient developed multiple bullae on violaceous patches on the trunk and extremities. The findings of histopathologic examinations were indicative of the diagnosis of FDEs. Although diclofenac is commonly used as a non-steroidal inflammatory drug, diclofenac-induced generalized FDE occurs rarely and has not been reported in Korea. With reuse of causative drugs, the size and number of lesions tend to increase.
Therefore, early diagnosis of FDE is important, and avoidance of repeated exposure to drugs should be educated.
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KEYWORD
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Fixed drug eruption, Diclofenac
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